Prednisolone 10mg ml Oral Solution Summary of Product Characteristics SmPC emc

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Restricted for cortisol replacement therapy of infants and young children withadrenal insufficiencywhere the hydrocortisone 10mg tablets cannot be used, either whole or halved, to administer the required dose. Steroid tablets, also called corticosteroid tablets, are a type of anti-inflammatory medicine used to treat a range of conditions. The incidence of acute renal crisis varies between the different subpopulations. The greatest risk has been reported in patients with diffuse systemic sclerosis.

Because of the possibility of fluid retention, care must be taken when corticosteroids are administered to patients with renal insufficiency or hypertension or congestive heart failure. • Patients who have had repeated courses of systemic corticosteroids, particularly if taken for greater than three weeks. For children under 2 years, Prednisolone Oral Solution can be used early in the management of moderate to severe episodes of acute asthma in the hospital setting, at a dose of 10mg for up to three days. Please note patients who are receiving or have received IMMUNOTHERAPYmay present with treatment related problems at anytime during treatment or up to 12 months afterwards. If you are unsure about the patient's regimen, be cautious and follow triage symptom assessment.

Specific dosage guidelines The following recommendations for some corticosteroid-responsive disorders are for guidance only. Acute or severe disease may require initial high dose therapy with reduction to the lowest effective maintenance dose as soon as possible. Dosage reductions should not exceed 5-7.5mg daily during chronic treatment. Caution is required in patients with systemic sclerosis because of an increased incidence of scleroderma renal crisis with hypertension and decreased urinary output observed with a daily dose of 15 mg or more prednisolone. Blood pressure and renal function (s-creatinine) should therefore be routinely checked. When renal crisis is suspected, blood pressure should be carefully controlled.

No change to pre-treatment normal - or fully active,able to carry on all pre-disease performance without restriction. Stent insertion - performance statusChemotherapy - performance statusRadiotherapy - any contraindications e.g. previous radiotherapy to chest. Inability to lie flat.If thrombus is present consider anticoagulation if no contraindications. Always make sure that the Acute Oncology Team are informed of patient's assessment and/ or admission as soon as possible.

Nil by mouth if abdominal pain or distension or abnormal abdominal X-ray. Secondary to SACT e.g. 5FU or CAPECITABINE, IRINOTECAN, ERLOTINIB any TKI or Targeted Therapy please see specific DRUG INFORMATION SHEET for specific management guidance. If haematology patient or strong suspicion of infective diarrhoea, withhold anti-diarrhoeal medication until stool result available. WITHHOLD SACT until Acute Oncology Team review and review all other medication as they may be contributing - if receiving Capecitabine or 5FU consider DPD deficiency.

Sheary postulated that the basis for the skin redness seen in these patients is due to an elevation in blood nitric oxide levels, which widens blood vessels, increasing blood flow to the skin. It has also been proposed that topical corticosteroids disrupt the epidermal barrier causing an initiation of cytokine cascade followed by an inflammatory response . Topical corticosteroids are known to constrict blood vessels in the skin and therefore some reddening of the skin would be expected on withdrawal. However, this specific kind of topical steroid withdrawal reaction could be an extreme form of this reaction.